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April 15, 2010PLoS PathogensOpen Access

The RING-CH Ligase K5 Antagonizes Restriction of KSHV and HIV-1 Particle Release by Mediating Ubiquitin-Dependent Endosomal Degradation of Tetherin

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Authors

CPClaire PardieuQueen Mary University of LondonRVRaphaël ViganGuy's HospitalSWSam J. WilsonInserm

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Pardieu et al. (2010) studied this question.

synapsesocial.com/papers/6a6ffb5bfebe604dd708cb5ehttps://doi.org/10.1371/journal.ppat.1000843
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Antagonism to and Intracellular Sequestration of Human Tetherin by the Human Immunodeficiency Virus Type 2 Envelope Glycoprotein2009 · 281 citations
  2. 2Downregulation of Major Histocompatibility Complex Class I Molecules by Kaposi's Sarcoma-Associated Herpesvirus K3 and K5 Proteins2000 · 461 citations
  3. 3Vpu Directs the Degradation of the Human Immunodeficiency Virus Restriction Factor BST-2/Tetherin via a βTrCP-Dependent Mechanism2009 · 347 citations