The work described in this paper is a continuation of observations already made in this laboratory on the antidiuretic action of nicotine (Burn, Truelove, and Burn, 1945; Walker, 1948). Taylor and Walker (1951) have recently shown that the action is followed by the appearance of an antidiuretic substance in the urine of man resembling in its properties the posterior lobe hormone and not nicotine.
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Burn et al. (1951) studied this question.
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