Why the study?
It was unknown whether reduced left ventricular ejection fraction is a risk factor for the development of peritonitis in peritoneal dialysis patients.
Does reduced LVEF increase the risk of peritonitis development in patients with peritoneal dialysis?
Does reduced LVEF increase the risk of peritonitis development in patients with peritoneal dialysis?
Reduced LVEF (<50%) is a significant risk factor for developing peritonitis, particularly enteric peritonitis, in patients undergoing peritoneal dialysis.
Answers are grounded in this paper and cite their sources.
Should not yet change peritonitis risk assessment in peritoneal dialysis; hypothesis-generating and requires prospective confirmation.
We present a single-center retrospective analysis of 228 Japanese patients with peritoneal dialysis, in which we examined whether reduced left ventricular ejection fraction (LVEF) is a risk factor for peritonitis development. Time-dependent multivariable-adjusted Cox proportional hazards models revealed that reduced LVEF (LVEF < 50% vs. preserved LVEF ≥ 50%, hazard ratio (HR) 2.10; 95% confidence interval (CI) 1.16-3.82) was associated with peritonitis. Qualitatively, similar associations with reduced LVEF (< 50%) were observed for enteric peritonitis (adjusted HR 7.68; 95% CI 2.51-23.5) but not for non-enteric peritonitis (adjusted HR 1.15; 95% CI 0.54-2.44). Reduced LVEF is associated with a significantly higher risk of subsequent peritonitis, particularly enteric peritonitis. These results indicate that patients with reduced LVEF may be at risk of enteric peritonitis from bowel sources caused by intestinal involvement due to cardiac dysfunction.
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Yamaguchi et al. (2023) studied this question.
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