Bacillus Calmette-Guerin administered intravenously or by aerosol to rhesus monkeys induced a much greater degree of protection against aerosol challenge with virulent Mycobacterium tuberculosis than intracutaneous bacillus Calmette-Guerin vaccination. the aerosol route of vaccination was not associated with any obvious adverse side effects and produced a very small degree of tuberculin skin hypersensitivity. Aerosol vaccination should be examined further to determine its potential application for vaccinating humans against tuberculosis.
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Barclay et al. (1973) studied this question.