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Cells abortively infected with oncogenic adenovirus (Ad) show evidence of abnormal cellular DNA repli-cation (Strohl 1973), and Ad mutants that are temper-ature-sensitive for viral DNA replication have altered abilities to transform the host cell (Williams et al. 1975). These effects are most probably a result of the expression of early viral proteins, which are necessary for viral DNA replication and which, in transformed cells, cause cellular DNA replication under conditions that restrict normal cells. Thus, in order to under-stand the process of Ad-induced cell transformation, it is necessary to understand the mechanism of initiation of viral DNA replication and the proteins involved in that process, and also the effect of viral infection on cellular DNA replication. Consequently, we have studied the replication of Ad DNA during productive infection and viral and cellular DNA synthesis during nonproductive infection. Ad DNA, isolated from the virion, exists as a linear double-stranded chromosome with molecular weight of 20 • 106-29 • 10 6 (Levine et al. 1976; Younghusband and Bellett 1971). DNA molecules from the human adenovirus types 2 and 5 (Ad2 and Ad5) contain a unique, nonpalindromic, inverted terminal repetition
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Stillman et al. (1979) studied this question.
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