Provides structural insights into myosin filaments of Lethocerus flight muscle, suggesting a mechanism for stretch activation.
Suggests myosin architecture enables tension sensing in stretch activation; leaves open functional validation and cardiac disease relevance.
. Threading separate paths through the forest of myosin coiled coils are four nonmyosin peptides. We suggest that the unusual position of the heads and the rod arrangement separated by nonmyosin peptides are adaptations for mechanical signal transduction whereby applied tension disrupts the myosin heads as a component of stretch activation.
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Hu et al. (2016) studied this question.
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