November 25, 2021International Journal of Molecular SciencesOpen Access

Dexmedetomidine Promotes Lipopolysaccharide-Induced Differentiation of Cardiac Fibroblasts and Collagen I/III Synthesis through α2A Adrenoreceptor-Mediated Activation of the PKC-p38-Smad2/3 Signaling Pathway in Mice

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Why the study?

Dexmedetomidine is commonly used as a sedative during critical illness, but its potential accelerative effect on LPS-mediated cardiac fibroblast differentiation and underlying mechanism were unexplored.

Population

Wild-type and α2A-AR knockout mice and isolated mouse cardiac fibroblasts

Comparison

Dexmedetomidine vs control in LPS-stimulated conditions

Design

Preclinical animal and cell-culture study

Authors

JLJia LiaoSuizhou Central Hospital KLKaiying LiNingxia Medical University XSXingyu SuWaseda University

Discussion

Member takes

Implication

Hypothesis-generating for DEX effects on cardiac fibrosis in sepsis models; leaves open human relevance and clinical sedation choices.

Structured PICO

Population

Wild-type and α2A-AR knockout mice, and isolated mouse cardiac fibroblasts

Intervention

Dexmedetomidine (DEX) combined with lipopolysaccharide (LPS) stimulation (in vivo exposure for 4 weeks)

Comparator

LPS stimulation alone or vehicle

Outcome

Expression of α-SMA, collagen I/III, and phosphorylation of p38 and Smad-3surrogate

Dexmedetomidine accelerates LPS-induced cardiac fibroblast differentiation and fibrosis via the α2A-AR/PKC-p38-Smad2/3 pathway in mice.

Cite This Study

Liao et al. (2021) studied this question.

synapsesocial.com/papers/6a7003a72163a0a01bc43cee https://doi.org/10.3390/ijms222312749

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Dexmedetomidine Promotes Lipopolysaccharide-Induced Differentiation of Cardiac Fibroblasts and Collagen I/III Synthesis through α2A Adrenoreceptor-Mediated Activation of the PKC-p38-Smad2/3 Signaling Pathway in Mice

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Dexmedetomidine Promotes Lipopolysaccharide-Induced Differentiation of Cardiac Fibroblasts and Collagen I/III Synthesis through α2A Adrenoreceptor-Mediated Activation of the PKC-p38-Smad2/3 Signaling Pathway in Mice

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider