The pathogenesis of encephalopathy in cholestasis results from the accumulation of unconjugated bilirubin and hydrophobic bile acids in the brain. Putrescine, spermidine and spermine are endogenous polyamines essential for cellular growth, proliferation and regeneration. The amino-acid L-methionine is required for the biosynthesis of polyamines. The aim of the study was to examine the effect of L-methionine in polyamine metabolism on the cholestatic brain of injured rats. Wistair rats were divided into 3 groups: I - control, II - bile duct ligated (BDL) rats, III - BDL rats treated with L-methionine (50 mg/kg BW). Cholestasis in rats brain increases the putrescine level (p0.001) and decreases spermidine and spermine concentrations (p0.05), in relation to controls. The activity of PAO is increased (p0.001) and activity of DAO is reduced (p0.001) in the brain of BDL rats compared with controls. Administration of L-methionine in BDL rats prevents disorders of the biosynthesis and catabolism of polyamines in the brain during cholestasis.
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Sokolović et al. (2006) studied this question.
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