Epidemiologic studies of childhood leukemia: Where do we go from here?

Much of our knowledge of the mechanisms of carcinogenesis has resulted from the study of rare cancers, including retinoblastoma, angiosarcoma, and vaginal clear cell carcinoma. Due to the heterogeneity of childhood leukemia, epidemiologic studies that focus on children with unique clinical and genetic manifestations of the disease could potentially lead to further understanding of leukemogenesis.