The distribution behavior of solutes containing a hydrophilic group, between aqueous and different organic phases, has been examined from the standpoint of the influence of the organic solvent. The distribution constant (Kd ) has been well correlated with the solubility of water in the organic phase (S H2O) by an equation of the form where the constant a approximates to unity for a solute with a single polar functional group. The dimerization behavior of solutes in different organic phases and the relationship between the solubility of water in a solvent and interfacial tension between water and that solvent have also been examined.
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Kojima et al. (1985) studied this question.
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