April 1, 1979BloodOpen Access

Congenital deficiency of blood clotting factors II, VII, IX, and X

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Population

1 patient congenitally deficient in blood clotting factors II, VII, IX, and X

Design

Case_report

Follow-up

15 years

Authors

KCKS ChungKonkuk University ABA BezeaudUniversity of North Carolina at Chapel Hill JGJC GoldsmithUnited States Department of Veterans Affairs

Discussion

Member takes

Implication

Supports combined functional-immunologic assays in unexplained coagulopathies; leaves open mechanistic confirmation of carboxylation defects.

Structured PICO

Population

1 patient congenitally deficient in blood clotting factors II, VII, IX, and X

Intervention

Vitamin K1 therapy

Outcome

Clotting activity and immunologic levels of factors II, VII, IX, and Xsurrogate

This case report describes a rare congenital abnormality characterized by a deficiency in vitamin-K-dependent clotting factors, likely due to a defective gamma-carboxylation mechanism or faulty vitamin K transport.

Cite This Study

Chung et al. (1979) studied this question.

synapsesocial.com/papers/6a7005f33ce530166bc2b756 https://doi.org/10.1182/blood.v53.4.776.776

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Implication

Supports combined functional-immunologic assays in unexplained coagulopathies; leaves open mechanistic confirmation of carboxylation defects.

Congenital deficiency of blood clotting factors II, VII, IX, and X

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Congenital deficiency of blood clotting factors II, VII, IX, and X

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider