QSAR analysis employing Kubinyi's bilinear model was applied to examine the relationship between the structure (characterized by the lengths of the terminal hydrocarbon chain, m , and of the hydrocarbon spacer chain, y ), lipophilicity (characterized by the chromatographic parameter R m and aggregation properties expressed through the critical micellar concentration c K ), and antimicrobial activity (characterized by the minimum inhibition concentration, MIC) of quaternary ammonium bolaamphiphiles. The log c K = f ( m ) dependence was found to be linear whereas the log (1/MIC) = f ( m ), log (1/MIC) = f ( y ), log (1/MIC) = f (log c K ) and log (1/MIC) = f ( R m ) dependences were nonlinear. The effect of the hydrophobic terminal chains ( m ) and of the hydrophobic spacer chain ( y ) on the aggregation properties and on the biological activity of the substances was studied.
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Pavlíková et al. (1995) studied this question.