September 1, 1999British Journal of PharmacologyOpen Access

Monophosphoryl lipid A provides biphasic cardioprotection against ischaemia‐reperfusion injury in rat hearts

View Full Paper

Ask AI

Bookmark

Why the study?

Does monophosphoryl lipid A provide cardioprotection against ischaemia-reperfusion injury in a rat model of myocardial infarction?

Structured PICO

Does monophosphoryl lipid A provide cardioprotection against ischaemia-reperfusion injury in a rat model of myocardial infarction?

Population

Rat model of myocardial infarction undergoing 20-min left coronary artery (LCA) occlusion and 48-h reperfusion

Intervention

Monophosphoryl lipid A (MLA) 0.5 or 1.0 mg kg-1, i.v., administered 0.5 h, 2 h, 24 h, or 72 h prior to occlusion

Comparator

Control (implied untreated or vehicle)

Outcome

Infarct size and incidence of ventricular fibrillation (VF) during ischaemiasurrogate

Monophosphoryl lipid A provides biphasic cardioprotection against ischaemia-reperfusion injury in rats, potentially mediated by enhanced Mn-SOD activity.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

MLA pretreatment attenuates VF and infarct size in rats; leaves open translation to human ischaemia-reperfusion injury.

Cite This Study

Yamashita et al. (1999) studied this question.

synapsesocial.com/papers/6a70088678a11c550e09d2da https://doi.org/10.1038/sj.bjp.0702809

View Full Paper

Ask AI

Bookmark

Monophosphoryl lipid A provides biphasic cardioprotection against ischaemia‐reperfusion injury in rat hearts

Structured PICO

Discussion

Implication

Cite This Study

Monophosphoryl lipid A provides biphasic cardioprotection against ischaemia‐reperfusion injury in rat hearts

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider