Key result
Female-specific atherosclerosis driver genes map predominantly to modulated smooth muscle cells controlled by Klf4.
Observational (n=320)
Yes
Sex-specific gene regulatory networks reveal that female key driver genes in atherosclerosis are predominantly associated with smooth muscle cell phenotypic switching, highlighting distinct molecular mechanisms of coronary artery disease between sexes.
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Hartman et al. (2021) conducted an observational in Atherosclerosis (n=320). Female sex vs. Male sex was evaluated on Sex differences in network activity and key driver genes within atherosclerotic tissues. Female-specific key driver genes in atherosclerosis are predominantly expressed by phenotypically modulated smooth muscle cells and affected by Klf4, driving sex differences in plaque pathobiology.
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