Key result
Embryonic stem cell transplantation shows cardiac regeneration promise in animal models despite substantial clinical hurdles.
Embryonic stem cells are a promising source for myocardial regeneration due to their pluripotency and plasticity. In theory, embryonic stem cells are capable of self-renewal in an unlimited fashion, and can differentiate into any cell type required for cell-based therapy, including cardiac myocytes. In recent years, embryonic stem cells have been transplanted for cardiac regeneration in animal models, and the results are encouraging. However, there are still many hurdles to be overcome for the clinical application of embryonic stem cells.
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Dai et al. (2006) conducted a review in Myocardial regeneration. Embryonic stem cell transplantation was evaluated. Embryonic stem cell transplantation for cardiac regeneration shows encouraging results in animal models, though many hurdles remain for clinical application.
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