Why the study?
Water caltrop pericarp has long been used to treat metabolic syndrome, but the bioactive substances and their pharmacological mechanisms remain unclear.
Does 1,2,3,6-tetra-O-galloyl-β-D-glucopyranoside (GA) improve high-fat diet-induced nonalcoholic fatty liver disease in mice?
Population
High-fat diet-induced NAFLD mice
Comparison
GA (15 and 30 mg/kg/day) vs control
Design
Animal study
Authors
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GA may benefit preclinical NAFLD; leaves open clinical translation without human trials.
Does 1,2,3,6-tetra-O-galloyl-β-D-glucopyranoside (GA) improve high-fat diet-induced nonalcoholic fatty liver disease in mice?
GA isolated from water caltrop pericarp shows potential as a therapeutic agent for NAFLD by improving lipid deposition, insulin resistance, and inflammation in a mouse model.
Lv et al. (2023) studied this question.
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