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November 2, 2015Scientific ReportsOpen Access

Cholesterol induces lipoprotein lipase expression in a tree shrew (Tupaia belangeri chinensis) model of non-alcoholic fatty liver disease

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Population

Tree shrew (Tupaia belangeri chinensis) model of non-alcoholic fatty liver disease (NAFLD)

Design

Preclinical

Follow-up

10 weeks

Authors

LZLinqiang ZhangJilin Agricultural UniversityZZZhiguo ZhangUniversity of Illinois Urbana-ChampaignYLYunhai LiThe University of Texas MD Anderson Cancer Center

Discussion

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Implication

Novel tree shrew NAFLD model extends preclinical tools; leaves open human translation pending validation.

Structured PICO

P
Population
Tree shrew (Tupaia belangeri chinensis) model of non-alcoholic fatty liver disease (NAFLD)
I
Intervention
High fat, cholesterol and cholate diet (HFHC) for 10 weeks, and Poloxamer 407 (P-407) inhibition of LPL
O
Outcome
Liver steatosis, inflammation, fibrosis, and lipid profile (ALT, AST, TC, LDL-c, HDL-c, TG)surrogate

A novel tree shrew model of NAFLD demonstrates that cholesterol induces lipoprotein lipase expression, and LPL inhibition improves steatosis and inflammation.

Cite This Study

Zhang et al. (2015) studied this question.

synapsesocial.com/papers/6a700a262163a0a01bc441b5https://doi.org/10.1038/srep15970

Topics

Lipid management
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