An antitumor agent from various Streptomyces species, the title compound 1, has been synthesized for the first time, as described here. Key steps involved include a ring-closing metathesis, a photochemically induced acylnitrene insertion process, and highly selective Julia olefinations for the preparation of E,E diene moieties. The macrocycle was formed from an intramolecular Horner-Wadsworth-Emmons olefination induced by barium hydroxide.
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Williams et al. (2000) studied this question.
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