Put a cap on it: Hairpin-shaped RNAs and dumbbell-shaped RNAs were prepared using a thiol–maleimino Michael addition and exhibited good serum and thermal stability. These capped structures were shown to be cleaved by Dicer and RNA interference (RNAi) experiments showed that RhpRNA (see picture, top right) was highly efficient at RNAi with an IC50 value of 6 pM.
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Lv et al. (2013) studied this question.
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