The dynamics of long chain macromolecules in field-inversion gel electrophoresis is studied by Monte Carlo simulation using a reptation model which includes tube length fluctuations. A sharp minimum in chain mobility is observed as the pulse duration is varied, occurring at longer pulse periods for larger chains. Detailed examination of the dynamics shows that the reduced mobility results from the chain being trapped in long-lived compact configurations which have no net translational motion.
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Thomas Duke (1989) studied this question.
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