Molecular Genetic Study of Finns With Hypoalphalipoproteinemia and Hyperalphalipoproteinemia

Two probands with HDL-C <0.2 mmol/L and two cohorts of smoking men with very low (0.2 to 0.7 mmol/L, n=156) or elevated (1.9 to 3.6 mmol/L, n=160) HDL-C levels, of Finnish descent.

Genetic screening for LCAT, LPL, and CETP mutations

Comparison between low HDL-C and high HDL-C cohorts

Frequency of specific genetic mutations affecting HDL-C levelssurrogate