What question did this study set out to answer?

To isolate and characterize the morphological, physical, and infective properties of incomplete particle populations of adenovirus type 16.

September 1, 1973Journal of General Virology

Incomplete Virus Particles of Adenovirus Type 16

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To isolate and characterize the morphological, physical, and infective properties of incomplete particle populations of adenovirus type 16.
Separated haemagglutinating adenovirus type 16 populations (I–VIII) using isopycnic centrifugation in cesium chloride gradients.
Evaluated particle morphology, [3H]-thymidine incorporation, and infectivity dose-response curves across the isolated fractions.
Analyzed the polypeptide profiles of complete versus incomplete particle populations using SDS-polyacrylamide gel electrophoresis.
Incomplete viral populations shared identical morphology with complete particles, with the five lightest fractions containing [3H]-thymidine and demonstrating multiplicity-dependent infectivity.
Electrophoresis of the lightest incomplete particle population showed a deficiency in three typical polypeptides alongside the presence of three novel, unique polypeptides not found in complete particles.
Specific characteristic polypeptides in both complete and incomplete populations exhibited high ratios of arginine over threonine.

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Implication

Experimental study demonstrates multiplicity-dependent infectivity in incomplete adenovirus type 16 particles, indicating partial viral genomes retain biological activity.

Cite This Study

Wadell et al. (1973) studied this question.

synapsesocial.com/papers/6a7013f631a3df8243285b91 https://doi.org/10.1099/0022-1317-20-3-287

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Implication

Experimental study demonstrates multiplicity-dependent infectivity in incomplete adenovirus type 16 particles, indicating partial viral genomes retain biological activity.

Incomplete Virus Particles of Adenovirus Type 16

Key Points

Discussion

Implication

Cite This Study

Incomplete Virus Particles of Adenovirus Type 16

Key Points

Discussion

Implication

Cite This Study

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