An ambitious goal in the area of nanobiosciences is to combine the functionality and stability of nanostructured inorganic solids with the structural variety and the self-organizing abilities of biochemical molecules. How the ligand shell of nanoparticles needs to be built up to achieve a stable and specific conjugation with biological molecules and to coordinate the chemical properties of nanoparticles and biomolecules is exemplified for gold nanoparticles conjugated with avidin (see picture).
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Schroedter et al. (2002) studied this question.
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