Key result
Increasing intravascular pressure progressively decreases peripheral vascular resistance across flow rates regardless of vasomotor tone.
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The relationship between flow and pressure was studied in the perfused hindquarters of the rat. The conclusion is drawn that peripheral resistance declines progressively with increasing intravascular pressure at various rates of flow, regardless of whether the vessels are relaxed or constricted.
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A. E. Doyle (1953) studied this question. Increasing intravascular pressure in the perfused rat hindquarter progressively decreases peripheral vascular resistance at various flow rates, regardless of vessel relaxation or constriction.
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