Population
Radiated, thrombopenic cats incapable of significant platelet regeneration (8 experiments)
Design
Preclinical
Follow-up
2 to 5 days
Authors
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Feline platelet kinetics data warrant caution against human extrapolation; leaves open species-specific validation in translational models.
In a feline model, cross-circulated platelets are utilized at a rate of approximately 2500 per cubic millimeter per hour, requiring total replacement every 2 to 5 days.
Lawrence et al. (1947) studied this question.
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