Familial Benign Chronic Neutropenia

Article1 November 1964Familial Benign Chronic NeutropeniaHUNTER O. CUTTING, J. EUGENE LANGHUNTER O. CUTTINGSearch for more papers by this author, J. EUGENE LANGSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-61-5-876 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptA unique congenital hematological syndrome has been studied in a kindred of three individuals during the past year in the Hematology Clinic of the United States Naval Hospital, San Diego, California. Investigation of this family has disclosed five additional cases. This syndrome is characterized by consistent neutropenia associated with normal to decreased leukocyte counts and usually with relative lymphocytosis, monocytosis, and variable eosinophilia.Familial benign chronic neutropenia is inherited as a nonsex-linked dominant. Similar cases were first reported by Glansslen (1), and subsequently by Bousser and Neyde (2), as "familial neutropenia." It is a relatively benign congenital anomaly, but unfortunately,...References1. GLANSSLEN M: Konstitutionelle familiare leukopenie (neutropenie). Klin. Wschr. 20: 922, 1941. CrossrefGoogle Scholar2. BOUSSERNEYDE JR: La neutropénie familiale. Sang 18: 521, 1947. MedlineGoogle Scholar3. WINTROBE MM: Clinical Hematology, 5th edition, Lea & Febiger, Philadelphia, 1961, p. 1103. Google Scholar4. KOSTMANN R: Infantile genetic agranulocytosis. Acta Paediat. (Stockholm) (Sup. 105) 45: 1, 1956. MedlineGoogle Scholar5. SPAETDAMESHEK THW: Chronic hypoplastic neutropenia. Amer. J. Med. 13: 35, 1952. CrossrefMedlineGoogle Scholar6. ADAMSWITTS EBLJ: Chronic agranulocytosis. Quart. J. Med. 18: 173, 1949. MedlineGoogle Scholar7. DAMESHEK W: A method for the simultaneous enumeration of blood platelets and reticulocytes. Arch. Intern. Med. (Chicago) 50: 579, 1932. 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ZUELZER WW: Myelokathexis—a new form of chronic granulocytopenia. New Eng. J. Med. 270: 699, 1964. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: HUNTER O. CUTTING; J. EUGENE LANGAffiliations: San Diego, CaliforniaFrom the United States Naval Hospital, San Diego, Calif.Requests for reprints should be addressed to Hunter O. Cutting, M.D., Scripps Clinic and Research Foundation, La Jolla, Calif. 92038. 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