Prevalence of erectile dysfunction and relationship between high sensitivity C-reactive protein, albuminuria, and cardiovascular risk factors with erectile dysfunction in coronary artery disease patients

INTRODUCTION: It is estimated that more than 150 million men worldwide have erectile dysfunction (ED) and this number will reach more than 300 million by 2025. There is strong evidence that ED increases the risk of future cardiovascular events. ED and CAD share common risk factors. High sensitivity C-Reactive Protein (hs-CRP) is an important inflammatory biomarker in subclinical atherosclerosis. Albuminuria is also a marker of widespread endothelial dysfunction and is thought to be associated with ED. This study was conducted to analyze the prevalence of ED and the relationship between hs-CRP, albuminuria, and cardiovascular risk factors with the occurrence of ED in CAD patients. MATERIALS AND METHODS: From July 2024 to October 2024, 288 CAD cases from Saiful Anwar general hospital heart clinic met the inclusion criteria. Data on hs-CRP, albuminuria, and cardiovascular risk factors such as age, hypertension, diabetes mellitus, dyslipidemia, obesity, and smoking were observed in relation to incidence of erectile dysfunction in CAD patients. Then logistic regression analysis was performed. RESULTS: There were 255 CAD patients (88.5%) who experienced ED. There was no significant relationship between hs-CRP and albuminuria with ED in CAD patients (p>0.05). Significant risk factors for ED in CAD patients were age (OR = 15.92; 95% CI = 4.67-54.22; p=0.000), triglycerides (OR = 2.52; 95% CI = 1.12-5.66; p=0.024), and smoking (OR = 0.29; 95% CI = 0.09-0.89; p=0.031). CONCLUSIONS: The prevalence of erectile dysfunction was 88.5% in patients with coronary artery disease. Hs-CRP and albuminuria did not have a significant relationship with the incidence of ED in patients with CAD. Risk factors that independently affect incidence of ED in patients with CAD are age, smoking, and hypertriglyceridemia.