Why the study?
What are the pharmacokinetics of pindolol and its relation to the time course of inhibition of exercise tachycardia in normal subjects?
Population
Normal subjects
Comparison
Pindolol 5, 10, and 20 mg orally and 3 mg or 5… vs Baseline/control
Design
Other
Follow-up
24 hours
Authors
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Provides PK/PD timing data in healthy subjects; leaves open translation to patients with cardiovascular disease.
What are the pharmacokinetics of pindolol and its relation to the time course of inhibition of exercise tachycardia in normal subjects?
Pindolol exhibits a plasma half-life of 2.9 hours with 53% bioavailability, and its peak inhibition of exercise tachycardia correlates with peak plasma concentrations.
Jennings et al. (1979) studied this question.
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