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Theoretical discussion on optimizing drug scheduling to maximize tumor uptake and minimize toxicity in normal tissues.
Using standard pharmacologic concepts, it is possible to show that changes in schedule will influence the relative influx of drug between various normal tissues and tumor. A line of investigation is discussed that should lead to optimization of influx into tumor tissue while minimizing uptake into dose limiting normal tissues.
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Arthur J. Weiss (1990) studied this question.
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