Why the study?
Does elective cardiac surgery alter local renin-angiotensin system expression in adipose tissue and contribute to postoperative insulin resistance in patients?
Population
10 patients undergoing elective cardiac surgery
Comparison
Elective cardiac surgery vs Baseline (beginning of surgery)
Design
Cohort
Follow-up
End of surgery
Authors
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May link epicardial angiotensinogen upregulation to postoperative insulin resistance; hypothesis-generating and should not yet change practice.
Does elective cardiac surgery alter local renin-angiotensin system expression in adipose tissue and contribute to postoperative insulin resistance in patients?
Major cardiac surgery increases angiotensinogen production specifically in epicardial adipose tissue, which may contribute to the development of postoperative insulin resistance.
Roubíček et al. (2008) studied this question.
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