Why the study?
What is the role of genetic factors in the mechanism of coronary artery remodeling and in-stent restenosis after stent implantation?
What is the role of genetic factors in the mechanism of coronary artery remodeling and in-stent restenosis after stent implantation?
Understanding genetic polymorphisms related to hemostasis, inflammation, and endothelial function may help in risk stratification for in-stent restenosis after angioplasty.
In the last 10 years the World has increased significantly the frequency of joint replacement in patients with coronary artery disease. Coronary angioplasty with stenting significantly improve the capacity and effectiveness of the treatment of coronary artery disease. However, an important factor limiting the effectiveness of endovascular treatment of restenosis remains the stented area.The article presents an overview of the most studied gene polymorphisms of hemostasis, inflammation system, the renin-angiotensin system, endothelial nitric oxide synthase, which can play a key role in the development of in-stent restenosis. Research in this area are significant and may help in understanding the mechanisms and risk stratification of restenosis after angioplasty.
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Винтизенко et al. (2015) studied this question.
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