The development of a novel assay to study EV-A71 recombination demonstrates the central role of the viral RNA-dependent RNA polymerase in the recombination process.
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May enable prediction of EV-A71 recombination events; leaves open clinical relevance of RdRp variants.
Recombination is a mechanism that contributes to genetic diversity. We describe the first assay to study EV-A71 recombination. Results from this assay mimic what is observed in nature and can be used by others to predict future recombination events within the enterovirus species A group. In addition, our results highlight the central role played by the viral RNA-dependent RNA polymerase (RdRp) in the recombination process. Further, our results show that changes to a conserved residue in the RdRp from different species groups have a similar impact on viable recombinant virus yields, which is indicative of conservation in mechanism.
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Woodman et al. (2018) studied this question.
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