Synthesis and antimicrobial evaluation of novel 1,3,4-thiadiazole derivatives of 2-(4-formyl-2-methoxyphenoxy) acetic acid

A series of 1,3,4-thiadiazole derivatives of 2-(4-formyl-2-methoxyphenoxy) acetic acid (6a–s) were synthesized by cyclization of carboxylic acid group of 2-(2-methoxy-4-(3-oxo-3-substituted phenylprop-1-enyl)phenoxy) acetic acid (4a–s) with thiosemicarbazide in the presence of POCl3 or PPA. The structures of the compounds were confirmed by IR, 1H NMR and mass analysis. All the compounds have been evaluated in vitro for their antimicrobial activities against several strains of microbes and show significant activity.