Beta-methylthiolation of ribosomal protein S12 is not a determinant of the streptomycin phenotype in Thermus thermophilus.
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Questions prior assumptions on ribosomal modification; leaves open alternative determinants of streptomycin phenotype in thermophiles.
Ribosomal protein S12 contains a highly conserved aspartic acid residue that is posttranslationally beta-methylthiolated. Using mass spectrometry, we have determined the modification states of several S12 mutants of Thermus thermophilus and conclude that beta-methylthiolation is not a determinant of the streptomycin phenotype.
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Carr et al. (2006) studied this question.
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