Understanding the role of leukocytes in the interplay between diabetes and heart failure may help in discovering new targeted therapies for diabetic cardiomyopathy.
Leukocyte modulation merits investigation in diabetic heart failure; leaves open clinical translation pending targeted trials.
Diabetes is predominant risk factor for cardiovascular diseases such as myocardial infarction and heart failure. Recently, leukocytes, particularly neutrophils, macrophages, and lymphocytes, have become targets of investigation for their potential role in a number of chronic inflammatory diseases such as diabetes and heart failure. While leukocytes contribute significantly to the progression of diabetes and heart failure individually, understanding their participation in the pathogenesis of diabetic heart failure is much less understood. The present review summarizes the role of leukocytes in the complex interplay between diabetes and heart failure, which is critical to the discovery of new targeted therapies for diabetic cardiomyopathy.
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Bajpai et al. (2018) studied this question.
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