Translating anti-corrosive and anti-biofouling strategies from implantable biomedical devices to sensor platforms for extreme environments

Implantable biomedical devices provide a mature interface-engineering toolkit and, with it, opportunities to translate for designing harsh-environment sensors. Measurement-integrity failures should be considered according to specific performance metrics such as drift, response-time inflation, and intermittent access rather than generic durability loss. In this perspective, we highlight transferable principles, including electrolyte exclusion via hermetic or defect-tolerant encapsulation, suppression of defect nucleation/growth in barrier stacks under thermo-mechanical cycling, and antifouling choices constrained by the sensing interface and calibration strategy. Because some antifouling layers protect surfaces yet degrade transduction by adding transport resistance or masking active sites, hybrid or active mitigation can outperform purely passive coatings.