Key result
Metabolomics methodologies advance target discovery and predictive phenotyping in cardiovascular and lipid metabolism research.
Metabolomics is the study of metabolite profiles in biological samples, particularly urine, saliva, blood plasma and fat biopsies. The metabolome is now considered by some to be the most predictive phenotype: consequently, the comprehensive and quantitative study of metabolites is a desirable tool for diagnosing disease, identifying new therapeutic targets and enabling appropriate treatments. A wealth of information about metabolites has been accumulated with global profiling tools and several candidate technologies for metabolomic studies are now available. Many high-throughput metabolomics methodologies are currently under development and have yet to be applied in clinical practice on a routine basis. In the cardiovascular field, few recent metabolomic studies have been reported so far. This minireview provides an updated overview of alternative technical approaches for metabolomics studies and reviews initial applications of metabolomics that relate to both cardiovascular disease and lipid metabolism research.
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Giovane et al. (2008) conducted a review in Cardiovascular disease and lipid metabolism. Metabolomic profiling was evaluated. Metabolomics methodologies provide an updated overview of technical approaches for evaluating new therapeutic targets and predictive phenotypes in cardiovascular and lipid metabolism research.
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