Effect of Atorvastatin on the levels of adiponectin and leptin and adiponectin-leptin ratio in the elderly and middle-aged patients with type 2 diabetes and combined hyperlipidemia

Objective To evaluate effects of Atorvastatin on the levels of adiponectin and leptin and adiponectin-leptin ratio in the elderly and middle-aged patients with type 2 diabetes and combined hyperlipidemia Methods Totally 80 the elderly and middle-aged patients with type 2 diabetes and combined hyperlipidemia were treated with Atorvastatin(10mg/d)for 12 weeks.Fasting plasma levels of glucose(FPG), glycosylated hemoglobin(HbA1c), total cholesterol(TC), triglyceride(TG), high-density lipoprotein cholesterol(HDL-C), low-density lipoprotein cholesterol(LDL-C), adiponectin(APN)and leptin(LEP)were measured at baseline and 12 weeks after treatment.And the adiponectin/leptin(A/L)ratio was calculated. Results Before versus 12 weeks after medication, TG〔(4.92±1.23)mmol/L vs.(4.26±1.07)mmol/L, t=11.124, P<0.001〕, TC〔(2.69±1.17)mmol/L vs.(1.66±1.01)mmol/L, t=24.816, P<0.001]and LDL-C[(2.79±1.02)mmol/L vs.(1.91±0.92)mmol/L, t=21.508, P<0.001]were decreased obviously; HDL-C increased obviously〔(1.03±0.30)mmol/L vs.(1.33±0.26)mmol/L, t=-12.011, P<0.001〕; APN increased slightly without statistical significance(P=0.064); LEP level decreased slightly without statistical significance(P=0.068), and A/L increased obviously(P<0.05). Conclusions Atorvastatin treatment can significantly decrease TG, TC and LDL-C level in the elderly and middle-aged patients with type 2 diabetes and combined hyperlipidemia, and significantly increase HDL-C as well as A/L level, while it has no obvious influence on APN and LEP.