Why the study?
Does terfenadine with or without alcohol impair performance on laboratory analogues of car driving in healthy female volunteers?
Does terfenadine with or without alcohol impair performance on laboratory analogues of car driving in healthy female volunteers?
High-dose terfenadine (240 mg) significantly impairs driving performance both alone and when combined with alcohol, highlighting the importance of evaluating behavioral effects across a range of doses.
May warrant caution with high-dose terfenadine in drivers; leaves open dose-response effects in clinical populations.
Twelve healthy female volunteers received acute doses of terfenadine, 60 mg, 120 mg, 240 mg or placebo, followed by a 'social' dose of alcohol equivalent to 0.5 g absolute alcohol/kg body weight. Performance was assessed on laboratory analogues of car driving both before and after alcohol administration. Terfenadine (240 mg) was found to significantly impair performance alone and following alcohol. The results demonstrate the importance of establishing the behavioural effects of drugs over a range of doses.
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Bhatti et al. (1989) studied this question.
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