Novel heterostructured Ru-doped TiO₂/CNTs hybrids with enhanced electrochemical sensing performance for Cetirizine

Quantification of bioactive compounds via electrochemical methods is a topic of great interest over the past decades, due to its versatility and accuracy of estimation at the trace level. In the present investigation, an antihistamine drug Cetirizine (CTZ) was quantified by the electrochemical technique using carbon sensor fabricated with coalesced ruthenium-doped titanium dioxide (Ru-TiO 2 ) nanoparticles and multi-walled carbon nanotubes (MWCNTs). The fabricated nanocomposite sensor offered four-folds augmented oxidation peak for CTZ compared to the nascent carbon sensor in pH 6.0 media. Electrochemical analysis of CTZ was performed by voltammetry techniques such as cyclic voltammetry (CV), square wave voltammetry (SWV) to estimate heterogeneous rate constant, a number of proton-electron transferred in the oxidation response. The method developed showed CTZ electrooxidation with a low detection limit value of 3.10 nM and hence, the method was used to evaluate CTZ in human urine as well as from the pharmaceutical formulations.