Key result
IL-18 +183 G-allele is linked to lower serum IL-18 levels in stable CAD patients.
Observational (n=1,205)
Answers are grounded in this paper and cite their sources.
BACKGROUND: Increased IL-18 serum levels have been associated with diabetes type 2, metabolic syndrome and the severity of atherosclerosis. The present study investigated the presence and influence of IL-18 genetic variants on gene- and protein expression in stable coronary artery disease (CAD) patients. METHODS: The +183 A/G (rs 5744292), -137 G/C (rs 187238) and -607 C/A (rs 1946518) polymorphisms were determined in 1001 patients with angiographically verified stable CAD, and in 204 healthy controls. IL-18 gene-expression was measured in circulating leukocytes in 240 randomly selected patients. Circulating IL-18 and IL-18 binding protein levels were measured immunologically in all patients. RESULTS: The +183 G-allele associated significantly with lower serum levels of IL-18 (p = 0.002, adjusted for age, glucose, body mass index and gender) and a 1.13- fold higher IL-18 gene-expression (p = 0.010). No influence was observed for the -137 G/C and -607 C/A polymorphisms. The IL-18 binding protein levels were not influenced by IL-18 genotypes. IL-18 levels were significantly higher in men as compared to women, and in patients with diabetes type 2 and metabolic syndrome compared to those without (p ≤ 0.001, all). The reduction in IL-18 levels according to the +183 G-allele was 3-4 fold more pronounced in diabetes and metabolic syndrome as compared to unaffected patients.Finally, the +183 AA genotype was more frequent in patients with hypertension (p = 0.042, adjusted for age, body mass index and gender). CONCLUSION: The reduction in serum IL-18 levels across increasing numbers of +183 G-alleles was especially apparent in patient with diabetes type 2 and metabolic syndrome, suggesting a beneficial GG genotype in relation to cardiovascular outcome in these patients. CLINICAL TRIAL REGISTRATION NUMBER: ClinicalTrials.gov: NCT00222261.
No takes yet. Share an insight, caveat, or question.
Opstad et al. (2011) conducted an observational in Stable coronary artery disease (n=1,205). IL-18 +183 A/G polymorphism (G-allele) vs. Absence of G-allele / other genotypes was evaluated on Serum levels of IL-18 (p=0.002). The IL-18 +183 G-allele was significantly associated with lower serum IL-18 levels (p=0.002) and 1.13-fold higher IL-18 gene expression (p=0.010) in stable CAD patients.
Synapse has enriched 10 related papers. Consider them for comparative context: