Key result
Cardiac biomarkers aid diagnosis, guide management, and improve risk stratification after neonatal hypoxic-ischaemia.
UNLABELLED: Following a perinatal hypoxic-ischaemic insult, term infants commonly develop cardiovascular dysfunction. Troponin-T, troponin-I and brain natriuretic peptide are sensitive indicators of myocardial compromise. The long-term effects of cardiovascular dysfunction on neurodevelopmental outcome following perinatal hypoxic ischaemia remain controversial. Follow-up studies are warranted to ensure optimal cardiac function in adulthood. CONCLUSION: Cardiac biomarkers may improve the diagnosis of myocardial injury, help guide management, estimate mortality risk and may also aid in longterm neurodevelopmental outcome prediction following neonatal hypoxic-ischaemia.
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Sweetman et al. (2011) conducted a review in Neonatal hypoxic ischaemia. Cardiac biomarkers (Troponin-T, Troponin-I, brain natriuretic peptide) was evaluated on Myocardial injury diagnosis, mortality risk, and neurodevelopmental outcome. Cardiac biomarkers may improve diagnosis of myocardial injury, guide management, estimate mortality risk, and aid in neurodevelopmental outcome prediction following neonatal hypoxic-ischaemia.
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