Population
5-day infarcted canine heart model (epicardial border zone myocytes/membranes)
Comparison
Examination of beta-adrenergic receptor complex… vs Remote, noninfarcted region of the same…
Design
Preclinical
Authors
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Border zone beta-adrenergic defects may impair post-MI responsiveness; hypothesis-generating in animal models and leaves open human relevance.
Multiple defects in the beta-adrenergic receptor complex develop in the epicardial border zone of infarcted hearts, contributing to impaired beta-adrenergic responsiveness and altered calcium current.
Steinberg et al. (1995) studied this question.
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