Why the study?
Do electromechanical and scar characteristics at the left ventricular lead implant site and overall dyssynchrony predict cardiac resynchronization therapy outcomes?
Do electromechanical and scar characteristics at the left ventricular lead implant site and overall dyssynchrony predict cardiac resynchronization therapy outcomes?
This study aims to define the relative importance of myocardial properties at the LV lead position and overall LV dyssynchrony for predicting CRT response.
Should not yet guide LV lead placement in CRT; leaves open the relative importance of site-specific properties versus global dyssynchrony.
Background In clinical patients undergoing cardiac resynchronization therapy (CRT), myocardial properties (mechanical, electrical, and scar-mediated) at the left ventricular (LV) lead position (LVLP) and overall LV dyssynchrony (circumferential uniformity ratio estimate [CURE, 0-1]) are of interest with respect to CRT outcomes. We sought to define the relative importance of these factors for CRT response in a clinical CMR study with longitudinal follow-up.
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Bilchick et al. (2014) studied this question.
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