Hepatic spheroids derived from human induced pluripotent stem cells in bio-artificial liver rescue porcine acute liver failure

Acute liver failure (ALF) is a complicated disorder showing a nearly 80% mortality rate, and there is currently no effective medical solutions for ALF except liver transplantation. 1 Bio-artificial liver (BAL) system is a device that consists of a bioreactor filled with hepatocytes, which could potentially rescue ALF patients by providing partial liver function until a suitable donor liver can be found or the native liver has self-regenerated. 2 , 3