Core myopathies involving calcium-conducting proteins carry a high or theoretically possible risk for malignant hyperthermia, which is critical for anesthetic management.
Warrants MH precautions in anesthesia for core myopathies with calcium protein defects; leaves open need for prospective validation.
In this article, we analyze myopathies with cores, for which an association to malignant hyperthermia (MH) has been suggested. We discuss the clinical features, the underlying genetic defects, subsequent effects on cellular calcium metabolism, and in vitro muscle responses to MH triggers. We describe in detail central core disease, multiminicore disease, and nemaline rod myopathy. We categorize the diseases according to the affected proteins and discuss the risk for MH, which is high or theoretically possible when the calcium-conducting proteins are affected.
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Klingler et al. (2009) studied this question.
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