Dynamically Crosslinked Gold Nanoparticle – Hyaluronan Hydrogels

Bioprinting consists of automated deposition of cells and biomaterials to mimic the architecture of a tissue. Gold nanoparticles act as dynamic, multivalent crosslinkers for thiol-modified hyaluronic acid and gelatin. The resulting synthetic extracellular matrix can be bioprinted into tubular constructs that support cell proliferation and matrix remodeling. The figure shows a view of a tissue construct (containing a fluorescent dye) in the x-y plane, and the inset shows the print head used.