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December 18, 2008Cerebrovascular Diseases96 citationsOpen Access

Safety and Outcome after Thrombolysis in Stroke Patients with Mild Symptoms

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Why the study?

Does intravenous recombinant tissue-type plasminogen activator improve outcomes in patients with mild but disabling stroke symptoms?

Population

32 patients presenting with mild but disabling stroke symptoms

Design

Cohort

Follow-up

3 months

Authors

MKMartin KöhrmannTNTim NoweHHHagen B. Huttner

Discussion

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Overview

Supports thrombolysis in mild disabling stroke per guidelines; leaves open randomized confirmation of net benefit.

Structured PICO

Does intravenous recombinant tissue-type plasminogen activator improve outcomes in patients with mild but disabling stroke symptoms?

P
Population
32 patients presenting with mild but disabling stroke symptoms
I
Intervention
Intravenous recombinant tissue-type plasminogen activator
O
Outcome
modified Rankin Scale (mRS) score at 3 months (dichotomized into favorable 0-1 vs unfavorable 2-6)hard clinical

Intravenous thrombolysis appears safe and effective in patients with mild but disabling stroke symptoms, supporting current guidelines that do not set a lower NIHSS limit.

Cite This Study

Köhrmann et al. (2008) studied this question.

synapsesocial.com/papers/6a7034a2f44fa9f079ddc60bhttps://doi.org/10.1159/000185607
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