Why the study?
What are the extracardiac effects and clinical applications of diltiazem and other calcium entry blockers in non-cardiac disorders?
What are the extracardiac effects and clinical applications of diltiazem and other calcium entry blockers in non-cardiac disorders?
Calcium entry blockers like diltiazem have extracardiac smooth muscle relaxing effects that may be clinically useful in various non-cardiac disorders.
Hypothesis-generating for non-cardiac uses of calcium entry blockers; prospective trials needed before clinical adoption.
Calcium entry blockers have a well documented relaxing effect of smooth muscle, vascular as well as non-vascular. Mainly as a consequence of this action, the drugs have been used for treatment of several non-cardiac disorders where hyperactivity of smooth muscle is considered to have an important role in the pathogenesis. In this short review some of these extracardiac effects of calcium entry blockers are discussed and also their clinical application.
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Karl‐Erik Andersson (1985) studied this question.
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