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Ductal infiltrating carcinoma of the breast is characterized by a remarkable amount of collagen fibrils surrounding nests and cords of neoplastic cells. Sequential extractions with pepsin release three classes of intact collagen chains, which have been identified as alpha 1 (I), alpha 2 (I) and alpha 1 (III) types. Alpha 1 (I) is prominent among these classes.
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Minafra et al. (1984) studied this question.
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